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In contrast, if one observational studyis affected by confounding and bias, which produce a spurious association,the combination of several observational studies, all affected by the sameissues, would compound (magnify) their effects and lead to a false but‘precise’ estimate of the effect size and possibly misleading conclusions[18]. “Middle East Respiratory Syndrome Coronavirus(MERS-CoV) – Update.” Global Alert and Response (GAR).

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Here the objectives and processes necessary todeliver results in accordance with the expected output (the target or goals) are set. Addi-tionally, drugs that may directly modulate appetite (suchas Rimonabant, an endocannabinoid-1 receptor blocker)might also show CR effects in sustained administrationby modulating consumption and hunger drive at centrallevels, but they also cannot be considered true CR mimet-ics

Addi-tionally, drugs that may directly modulate appetite (suchas Rimonabant, an endocannabinoid-1 receptor blocker)might also show CR effects in sustained administrationby modulating consumption and hunger drive at centrallevels, but they also cannot be considered true CR mimet-ics.